United defender Di’Shon Bernard, one of three teenagers who made their senior debut for the English team, deflected a shot by Antonio Rukavina into his own net in the 62nd for what proved to be the winning goal.
It was the first loss of the Europa League campaign for United, which had already secured a spot in the knockout stage and leads Group L with 10 points. Alkmaar had a chance to overtake United when it played Partizan Belgrade later.
Astana is last despite earning its first three points.
Lingard marked his